Azelaic Acid Market Is Encouraged to Reach USD 422.21 Million by 2033 at a CAGR of 7.0%

Tajammul Pangarkar
Tajammul Pangarkar

Updated · Jun 7, 2024

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Introduction

The global Azelaic Acid Market, valued at USD 218.29 million in 2022, is projected to grow at a steady CAGR of 7.0%, reaching USD 422.21 million by 2032. This growth is primarily driven by increasing demand for bio-lubricants and the use of azelaic acid in the cosmetics industry due to its anti-inflammatory and antimicrobial properties, which make it effective in treating skin conditions like acne and rosacea. The market is also benefiting from rising consumer preference for natural ingredients in cosmetics.

However, the market faces challenges such as competition from substitute di-carboxylic acids like sebacic acid, which can limit growth to some extent. Recent developments in the market include strategic expansions and product innovations by key players such as Emery Oleochemicals, which announced an expansion of its azelaic acid production capacity set to complete in 2024. This expansion aims to meet the growing demand for azelaic acid, particularly in North America and Asia-Pacific, regions that are seeing significant market activity and investment opportunities​​​​​​​​​​​.

In the rapidly evolving Azelaic Acid Market, key players are actively pursuing strategies such as acquisitions, mergers, and new product launches to strengthen their market positions and respond to the growing demand for azelaic acid products. Here are some recent developments involving the mentioned companies:

Emery Oleochemicals has recently announced a significant expansion of its azelaic acid production capabilities at its Cincinnati facility, set to complete in 2024. This expansion aims to double the current production capacity to better meet the increasing demand for bio-based and sustainable chemical solutions globally​​.

Matrica has partnered with Collistar, an Italian cosmetics firm, to develop a new range of skincare products that include azelaic acid. This collaboration is part of Matrica’s strategy to enhance its product offerings in the cosmetics sector, with the launch expected in early 2024​​.

Overall, while the azelaic acid market is poised for significant growth, it must navigate the availability of substitutes and stringent regulations, particularly in the cosmetics segment, to fully capitalize on the emerging opportunities in natural and bio-based product sectors.

Global azelaic acid market

Key Takeaways

  • Market Growth: The global azelaic acid market is currently undergoing substantial growth, projecting a Compound Annual Growth Rate (CAGR) of 7.0% during the forecast period 2023 to 2032.
  • Product Type Analysis: In terms of product types, the azelaic acid market is categorized into three segments: Polymer, Pharmaceutical, and Technical. The pharmaceutical-grade segment emerged as the dominant force in the market in 2022, securing a substantial revenue share of 49.6%.
  • Applications: Application, the azelaic acid market is divided into Lubricants, Plastics, Pharmaceuticals, and Cosmetics Electronics, Personal Care, and Other Applications. Among these, the plastics segment stood out as the market leader, commanding a substantial 38.6% revenue share in 2022.
  • Regional Analysis: In the regional context, North America constituted 38.7% of azelaic acid consumption by revenue. Following closely, Europe accounted for approximately 20% of the revenue share.

Azelaic Acid Statistics

  • Commercially available topical formulations with cosmetic and drug status contain 5% to 20% AZA in the form of gels and creams.
  • Structurally, it is a 1,7-heptane dicarboxylic acid having 9 carbon atoms
  • Absorption after topical administration of AZA varies, depending on the formulation used, between 3% (ointment, emulsion) and 8% (gel) of the dose administered.
  • Compared to the placebo, the foam with 15% AZA was more effective (32.0% vs. 23.5%; p < 0.001)
  • In two separate studies, topically applied 15% AZA was shown to be more effective than 0.75% and 1% and metronidazole gel, respectively, in reducing the percentage of inflammatory lesions and erythema
  • The largest study conducted by Balińa and Graupe compared the efficacy of a 20% AZA cream and a 2% hydroquinone cream applied twice daily for 24 weeks.
  • Formulations of azelaic acid consist of gels, creams, and foams with up to 20% concentration.
  • One study that compared results of European clinical trials showed azelaic acid 20% cream is as effective as tretinoin 0.05%, benzoyl peroxide 5%, and topical erythromycin
  • 2%.114 It is similar to benzoyl peroxide, but there is less evidence of its usefulness.
  • The recommended dosage is 20% cream for acne vulgaris and 15% gel for acne rosacea, both applied one to two times a day.
  • In a multicenter, double-blind, randomized study, 88 men and 62 women with acne vulgaris were randomly assigned in equal numbers to azelaic acid 5%, clindamycin 2%, or the combination
  • Initially, AzA was released in a 20% cream formulation and was shown in this vehicle to be effective in the treatment of mild to moderate rosacea.
  • A 15% gel formulation of AzA vastly improved the delivery of AzA and is superior in head-to-head studies to the 20% AzA cream.
  • Comparison of therapeutic effects of 20% azelaic acid and 4% hydroquinone cream in the treatment of melasma.
  • Azelaic acid is effective against several skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%
  • Comparison of therapeutic effects of 20% azelaic acid and 4% hydroquinone cream in the treatment of melasma

Emerging Trends

Emery Oleochemicals has notably expanded its azelaic acid production capabilities, aiming to double its production by 2024. This expansion is designed to meet growing demands, particularly in bio-based and sustainable chemical solutions​​.

Matrica is venturing into the cosmetics sector by collaborating with Italian cosmetics firm Collistar to develop a new skincare product line featuring azelaic acid, anticipated to launch in early 2024​​.

Croda Sipo (Sichuan) Co., Ltd. continues to innovate in the specialty chemicals arena, though specific recent developments weren’t detailed. The company is well-known for its focus on sustainable and efficient chemical solutions​​.

Nantong Hengxing Electronic Materials and Jiangsu Senxuan Pharmaceutical and Chemical Co., Ltd. are enhancing their market positions through broadened production and improved quality of azelaic acid, although specific recent activities were not highlighted. These companies are integral in supplying azelaic acid and other related chemicals​​​​.

Matrìca S.p.A. has been involved in sustainable industrial processes to produce azelaic acid and other bioproducts, focusing on integrating green chemistry​​.

Use Cases

  • Acne Treatment: Azelaic acid is highly effective for treating mild to moderate acne due to its antibacterial properties that reduce the growth of acne-causing bacteria in the follicles. It also has keratolytic properties, improving the disordered growth of skin cells that can block pores​​​​.
  • Rosacea: It is commonly prescribed for managing rosacea, helping reduce redness and inflammation. Azelaic acid’s anti-inflammatory properties make it suitable for calming the skin in rosacea patients​​​​.
  • Hyperpigmentation: Azelaic acid helps in treating hyperpigmentation by inhibiting tyrosinase, an enzyme involved in melanin production. This makes it effective in lightening dark spots caused by acne, sun exposure, or aging​​.
  • Skin Texture and Tone: It helps to smooth the skin and even out skin tone due to its exfoliating properties. This is beneficial in improving overall skin appearance, making it appear more uniform and reducing the visibility of blemishes​​.
  • Antioxidant Benefits: Azelaic acid also acts as an antioxidant, protecting the skin from free radical damage, which can accelerate skin aging and degradation​​.

Key Players Analysis

Emery Oleochemicals is a key player in the azelaic acid market, known for its commitment to sustainability and innovation in bio-based chemical solutions. The company recently announced a significant expansion at its Cincinnati facility, set to double its azelaic acid production by 2024. This expansion is aimed at meeting the increasing demand for eco-friendly and sustainable products, underlining Emery Oleochemicals’ role in supporting various industrial applications with environmentally responsible ingredients​​.

Matrica operates in the azelaic acid sector with a focus on sustainable and innovative product solutions. It is a joint venture between Novamont and Versalis and has developed a strategic partnership with the Italian cosmetics firm Collistar. Together, they are set to launch a new skincare line featuring azelaic acid in early 2024, highlighting Matrica’s role in integrating green chemistry into commercial products that cater to the growing demand for natural cosmetic ingredients​​.

Croda Sipo (Sichuan) Co., Ltd., a subsidiary of Croda International Plc, plays a significant role in the azelaic acid market. The company focuses on producing high-quality chemical solutions and has been instrumental in advancing sustainable practices within the industry. Croda Sipo’s efforts are geared towards innovating product lines that meet the growing demand for environmentally friendly and effective chemical ingredients, making significant contributions to the development of azelaic acid applications in various sectors.

Nantong Hengxing Electronic Materials, located in China, is involved in the azelaic acid market primarily through the supply of key raw materials needed for the production of azelaic acid. This company supports the chemical and electronic industries with its products, helping to meet the increasing global demand for azelaic acid used in high-performance applications. Nantong Hengxing focuses on quality and sustainable practices, aiming to enhance the supply chain efficiency for azelaic acid and related chemical products.

Jiangsu Senxuan Pharmaceutical and Chemical Co., Ltd. is a notable player in the azelaic acid sector, specializing in the production of high-purity chemical substances. The company’s focus on azelaic acid involves manufacturing it for various applications, including pharmaceuticals and cosmetics. Jiangsu Senxuan emphasizes innovation and quality in its production processes, aiming to meet the stringent standards required in healthcare and beauty industries, thereby supporting the growing demand for effective and safe azelaic acid-based products.

Matrìca S.p.A. is deeply involved in the azelaic acid sector through its commitment to green chemistry and sustainable processes. As a joint venture between Novamont and Versalis, Matrìca is focused on transforming vegetable oils into biodegradable and environmentally friendly chemicals, including azelaic acid. Their work supports the cosmetics and pharmaceutical industries with natural and sustainable ingredients, aligning with global trends towards eco-friendly and sustainable products. Matrìca’s efforts in azelaic acid production highlight their role in promoting sustainable development within the chemical industry.

Hubei TuoChu Kangyuan Pharmaceutical Co., Ltd focuses on the production and development of azelaic acid, particularly emphasizing its applications in the pharmaceutical industry. While specific details on their recent innovations or expansions in azelaic acid production are not widely publicized, the company is recognized for its commitment to quality and regulatory compliance, ensuring that its azelaic acid products meet the high standards required for medical and cosmetic applications.

Croda Sipo, a key entity in the azelaic acid market, is known for its innovative approach in the bio-based chemicals sector. As a subsidiary of Croda International Plc, Croda Sipo specializes in the production of azelaic acid used in various applications, including pharmaceuticals and cosmetics. The company focuses on sustainable practices and the development of high-quality azelaic acid that supports environmentally friendly solutions and meets growing market demands.

BASF is a prominent player in the azelaic acid market, offering high-purity azelaic acid products tailored for pharmaceutical and dermatological applications. Their product, Dermaz® 99, is utilized in treating acne vulgaris, rosacea, and hyperpigmentation disorders. BASF’s commitment to quality and sustainability is evident in their manufacturing processes and the comprehensive range of products they provide to enhance health and nutrition globally. The company leverages advanced technologies and a sustainable supply chain to meet the diverse needs of the healthcare sector, ensuring high standards across all product offerings​​​​.

Conclusion

Azelaic acid stands out in the skincare and pharmaceutical sectors for its multifaceted applications and significant benefits. Renowned for its efficacy in treating conditions like acne, rosacea, and hyperpigmentation, azelaic acid is valued for its antibacterial, anti-inflammatory, and skin-lightening properties​​​​. Its ability to improve skin texture and tone while minimizing the risk of side effects makes it a preferred choice among dermatologists and patients alike​​​​. As the demand for sustainable and effective skincare solutions grows, azelaic acid continues to gain prominence, driven by consumer preferences for natural ingredients and gentle skincare regimens​​​​. Moving forward, the azelaic acid market is poised for robust growth, with ongoing research likely to expand its applications and enhance its appeal in global health and beauty industries.

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Tajammul Pangarkar

Tajammul Pangarkar

Tajammul Pangarkar is a tech blogger that frequently contributes to numerous industry-specific magazines and forums. Tajammul longstanding experience in the fields of mobile technology and industry research is often reflected in his insightful body of work. His interest lies in understanding tech trends, dissecting mobile applications, and in raising a general awareness of technical know-how. When he’s not ruminating about various happenings in the tech world, he can be usually found indulging in his next favorite interest - table tennis.

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